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KMID : 0363420080220010001
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Journal of Korean Oriental Pediatrics
2008 Volume.22 No. 1 p.1 ~ p.11
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An Experimental Study on the Anticonvulsive Effects of Jisungbomuyngtan
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Kim Duk-Gon
Lee Hee-Sung
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Abstract
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Objectives : In order to investigate the anticonvulsive effects of Jisungbomuyngtan, the experiments were done in mice.
Methods :After solid extracts of Jisungbomuyngtan was orally administered to mice, four types of convulsion were induced in mice by ECT, strychnine, picrotoxin, caffein. Each of the time to convulsion and death was measured.
Results : 1. The solid extracts of Jisungbomuyngtan showed a remarkable effect in delaying the onset of convulsion induced by ECT 2. In case of convulsion induced by strychnine, the solid extracts of Jisungbomuyngtan revealed a slight, but not statistically significant effect. 3. Considerable prolongation of time to death was observed in convulsion induced by picrotoxin due to the anticonvulsive effect of Jisungbomuyngtan. 4. The anticonvulsive effect of Jisungbomuyngtan was not found in convulsion induced by caffein.
Conclusions : Jisungbomuyngtan effect remarkably in delaying the onset of convulsion induced by ECT. But slightly effect by strychnine. And Jisungbomuyngtan effect in prolonging time to death in convulsion induced by picrotoxin, but not found in convulsion induced by caffein.
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KEYWORD
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Jisungbomuyngtan, Anticonvulsive Effects, ECT, Strychnine, Picrotoxin, Caffein
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